Nature Communications (Nov 2021)
Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
- Darci Phillips,
- Magdalena Matusiak,
- Belén Rivero Gutierrez,
- Salil S. Bhate,
- Graham L. Barlow,
- Sizun Jiang,
- Janos Demeter,
- Kimberly S. Smythe,
- Robert H. Pierce,
- Steven P. Fling,
- Nirasha Ramchurren,
- Martin A. Cheever,
- Yury Goltsev,
- Robert B. West,
- Michael S. Khodadoust,
- Youn H. Kim,
- Christian M. Schürch,
- Garry P. Nolan
Affiliations
- Darci Phillips
- Department of Microbiology & Immunology, Stanford University School of Medicine
- Magdalena Matusiak
- Department of Pathology, Stanford University School of Medicine
- Belén Rivero Gutierrez
- Department of Pathology, Stanford University School of Medicine
- Salil S. Bhate
- Department of Microbiology & Immunology, Stanford University School of Medicine
- Graham L. Barlow
- Department of Microbiology & Immunology, Stanford University School of Medicine
- Sizun Jiang
- Department of Microbiology & Immunology, Stanford University School of Medicine
- Janos Demeter
- Department of Microbiology & Immunology, Stanford University School of Medicine
- Kimberly S. Smythe
- Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center
- Robert H. Pierce
- Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center
- Steven P. Fling
- Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center
- Nirasha Ramchurren
- Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center
- Martin A. Cheever
- Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center
- Yury Goltsev
- Department of Microbiology & Immunology, Stanford University School of Medicine
- Robert B. West
- Department of Pathology, Stanford University School of Medicine
- Michael S. Khodadoust
- Division of Oncology, Stanford University School of Medicine
- Youn H. Kim
- Department of Dermatology, Stanford University School of Medicine
- Christian M. Schürch
- Department of Microbiology & Immunology, Stanford University School of Medicine
- Garry P. Nolan
- Department of Microbiology & Immunology, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-26974-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
PD-1 blockade is effective for only a subset of patients with cutaneous T cell lymphomas. Here, the authors report a spatial biomarker that uses immune and cancer cell topography to predict response to PD-1 blockade in this disease.
