In vitro biological evaluation of Steroidal Saponins from seeds of Crotalaria verrucosa L. for cancer studies

Abstract

Saponins are a broad category of molecules categorized based on their chemical structure and found worldwide. Because of their complicated chemical structure and extensive therapeutic and pharmacological effects, saponins, derived from naturally occurring medicinal plants, have sparked a lot of research interest. Saponin applications have grown in popularity in recent years because of a variety of factors, including their biological (anti-cholesterol and anti-cancer) medical and pharmaceutical activities. Researchers have concentrated on bridging the gap between their chemical structure and biological activity because of their complex chemical composition and lesser-known applicability as a natural anticancer drug. The aim of the study was to identify and describe steroidal saponins from natural plant sources like Crotalaria verrucosa, as well as to evaluate their biological activity against breast and prostate cancer cells. Our data strongly suggest that steroidal saponins may aid in cancer prevention. The findings of our study strongly indicate that steroidal saponins exhibit potential in cancer prevention. By bridging the knowledge gap between the chemical composition of these compounds and their biological effects, this research contributes valuable insights into the promising role of saponins, particularly steroidal variants, as potential natural agents in the fight against cancer

Keywords

• Saponins
• Steroidal saponins
• Crotalaria verrucosa
• Anti-cancer
• HeLa and MCF 7 cells