Deep Brain Stimulation Withdrawal Syndrome, a Rare Life-Threatening Condition in Neurology and Neurosurgery

Abstract

The article addresses an acute condition associated with an abrupt cessation of neurostimulation of deep brain structures, which is manifested by acute hypokinesia and rigidity with further development of akinesia, anarthria and dysphagia. This may result in the need for emergency hospitalization and admission to an intensive care unit. The article presents literature review and clinical case reports. We discuss causes and approaches to the prevention and management of acute decompensation in patients with Parkinson's disease associated with abrupt deep brain stimulation cessation.

Keywords

• neurostimulation of deep brain structures
• parkinson's disease
• akinesia
• parkinsonian hyperpyrexia syndrome
• malignant neuroleptic syndrome
• withdrawal syndrome
• deep brain stimulation