Photoacoustic imaging for monitoring periodontal health: A first human study

Colman Moore; Yuting Bai; Ali Hariri; Joan B. Sanchez; Ching-Yu Lin; Sreenivas Koka; Parish Sedghizadeh; Casey Chen; Jesse V. Jokerst

Photoacoustics (Dec 2018)

Photoacoustic imaging for monitoring periodontal health: A first human study

Colman Moore,
Yuting Bai,
Ali Hariri,
Joan B. Sanchez,
Ching-Yu Lin,
Sreenivas Koka,
Parish Sedghizadeh,
Casey Chen,
Jesse V. Jokerst

Affiliations

Colman Moore: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive. La Jolla, CA, 92092, USA
Yuting Bai: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive. La Jolla, CA, 92092, USA
Ali Hariri: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive. La Jolla, CA, 92092, USA
Joan B. Sanchez: Herman Ostrow School of Dentistry, University of Southern California, 925 West 34th Street, Los Angeles, CA, 90089, USA
Ching-Yu Lin: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive. La Jolla, CA, 92092, USA
Sreenivas Koka: School of Dentistry, University of California, Los Angeles, 714 Tiverton Ave, Los Angeles, CA, 90024, USA; Koka Dental Clinic, 8031 Linda Vista Rd, San Diego, CA, 92111, USA
Parish Sedghizadeh: Herman Ostrow School of Dentistry, University of Southern California, 925 West 34th Street, Los Angeles, CA, 90089, USA
Casey Chen: Herman Ostrow School of Dentistry, University of Southern California, 925 West 34th Street, Los Angeles, CA, 90089, USA
Jesse V. Jokerst: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive. La Jolla, CA, 92092, USA; Materials Science Program, University of California, San Diego, 9500 Gilman Drive. La Jolla, CA, 92092, USA; Department of Radiology, University of California, San Diego, 9500 Gilman Drive. La Jolla, CA, 92092, USA; Corresponding author at: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive. La Jolla, CA, 92092, USA.

Journal volume & issue: Vol. 12
pp. 67 – 74

Abstract

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The gold-standard periodontal probe is an aging tool that can detect periodontitis and monitor gingival health but is highly error-prone, does not fully characterize the periodontal pocket, and causes pain. Photoacoustic imaging is a noninvasive technique that can address these limitations. Here, a range of ultrasound frequencies between 16–40 MHz were used to image the periodontium and a contrast medium based on cuttlefish ink was used to label the pockets. A 40 MHz ultrasound frequency could spatially resolve the periodontal anatomy, including tooth, gum, gingival margin, and gingival thickness of tooth numbers 7–10 and 22–27. The photoacoustic-ultrasound measurements were more precise (0.01 mm) than those taken with physical probes by a dental hygienist. Furthermore, the full geometry of the pockets could be visualized with relative standard deviations of 10% (n = 5). This study shows the potential for non-invasive monitoring of periodontal health with photoacoustic-ultrasound imaging in the dental clinic. Keywords: Photoacoustic imaging, Periodontal disease, Diagnosis, Gingival thickness, Pocket depth, Periodontal charting, Melanin nanoparticles

Published in Photoacoustics

ISSN: 2213-5979 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Physics: Acoustics. Sound; Science: Physics: Optics. Light
Website: http://www.journals.elsevier.com/photoacoustics/

About the journal