Recurrence of Henoch Schoenlein Purpura Nephritis in Children: A Retrospective Study
Lydia Mukanhaire,
Xianguo Ren,
Guangling Liu,
Ting Wang,
Yeukai Y. Kasumba,
Xiaohui Zhou,
Hongjun Peng
Affiliations
Lydia Mukanhaire
School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China; Department of Pediatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, 211166, China; Department of Pediatrics, Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, 210008, China
Xianguo Ren
Department of Pediatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, 211166, China
Guangling Liu
Department of Pediatrics, Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, 210008, China
Ting Wang
Department of Pediatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, 211166, China
Yeukai Y. Kasumba
School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China
Xiaohui Zhou
School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China; Corresponding author. School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China.
Hongjun Peng
Department of Pediatrics, Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, 210008, China; Corresponding author. Department of Pediatrics, Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, 210008, China.
The aim of the study was to identify predictive patient characteristics for Henoch Schoenlein Purpura (HSPN) relapse in childhood HSPN. One hundred and thirty-five Chinese children with HSPN were enrolled in this study, mean age 10.25 ± 3.39 years. The pathology of HSPN was according to the International Study of Kidney Disease in Children criteria.(ISKDC); ISKDC II(mesangial proliferation (MP)) AND ISKDC III (MP with <50 % crescents).Recurrence of HSPN was observed in 66.3 % patients; male to female ratio (2:1)Statistically significant correlation existed between biopsy grade(p < 0.001), gender(p < 0.001),age ranges(p = 0.002) and treatment regimen (p < 0.001)in the frequency of recurrent HSPN episodes. We identified some significant predictors for HSPN relapse such as the severity of HSPN, adjunctive therapies administered to these patients,and close attention should be paid in patients between the ages 7 and 12 years old. In addition, the use of mycophenolate mofetil as an adjunctive therapy in the treatment of HSPN may reduce the frequency of HSPN relapse episodes in children.
