Data of cytotoxicity, p53 and Akt downstream proteins and physiological indexes in hepatocellular carcinoma cells or HepG2-bearing nude mouse model administered by α-Humulene
Hao Chen,
Ji Hao,
Yanzhang Wen,
Yibing Lv,
Lu Chen,
Jingquan Yuan,
Xinzhou Yang
Affiliations
Hao Chen
Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530001, China; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China
Ji Hao
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China
Yanzhang Wen
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China
Yibing Lv
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China
Lu Chen
Guangxi Institute of Medicinal Plant, Nanning, 530023, China
Jingquan Yuan
Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530001, China; Guangxi Institute of Medicinal Plant, Nanning, 530023, China; Corresponding author. Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530001, China.
Xinzhou Yang
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China; Corresponding author.
This data article contains data related to the research article entitled “α-Humulene inhibits hepatocellular carcinoma (HCC) cell proliferation and induces apoptosis through the inhibition of Akt signaling” (Chen et al., 2019) [1]. The article focuses on the antiproliferation of α-Humulene (HML) and the mechanisms involved in HCC cells inhibition. In this data, cytotoxicity of HML in several HCC cell lines are reported, together with the changes in proteins involving in p53 and Akt downstream. Weight curve, blood biochemical parameters and organ indices from HepG2-bearing nude mouse model are also provided, suggesting the potential side effects in HML administration. Keywords: α-Humulene, Hepatocellular carcinoma, Cytotoxicity, Akt, Side effects
