The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer

Minakshi Gandhi; Matthias Groß; Jessica M. Holler; Si’Ana A. Coggins; Nitin Patil; Joerg H. Leupold; Mathias Munschauer; Monica Schenone; Christina R. Hartigan; Heike Allgayer; Baek Kim; Sven Diederichs

doi:10.1038/s41467-020-17007-9

Nature Communications (Jun 2020)

The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer

Minakshi Gandhi,
Matthias Groß,
Jessica M. Holler,
Si’Ana A. Coggins,
Nitin Patil,
Joerg H. Leupold,
Mathias Munschauer,
Monica Schenone,
Christina R. Hartigan,
Heike Allgayer,
Baek Kim,
Sven Diederichs

Affiliations

Minakshi Gandhi: Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ)
Matthias Groß: Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ)
Jessica M. Holler: Department of Pediatrics, School of Medicine, Emory University
Si’Ana A. Coggins: Department of Pediatrics, School of Medicine, Emory University
Nitin Patil: Department of Experimental Surgery—Cancer Metastasis, Medical Faculty Mannheim, Centre for Biomedicine and Medical Technology Mannheim, University of Heidelberg
Joerg H. Leupold: Department of Experimental Surgery—Cancer Metastasis, Medical Faculty Mannheim, Centre for Biomedicine and Medical Technology Mannheim, University of Heidelberg
Mathias Munschauer: Broad Institute of MIT and Harvard
Monica Schenone: Broad Institute of MIT and Harvard
Christina R. Hartigan: Broad Institute of MIT and Harvard
Heike Allgayer: Department of Experimental Surgery—Cancer Metastasis, Medical Faculty Mannheim, Centre for Biomedicine and Medical Technology Mannheim, University of Heidelberg
Baek Kim: Department of Pediatrics, School of Medicine, Emory University
Sven Diederichs: Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ)

DOI: https://doi.org/10.1038/s41467-020-17007-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Despite some well-characterized functions in cancer, the impact of most long non-coding RNAs remains unknown. Here, the authors discover the lncRNA lincNMR which is upregulated in cancer and drives cell proliferation by interacting with YBX1 and controlling nucleotide metabolism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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