Nature Communications (May 2016)
CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation
- Wenqiang Cao,
- Jing Guo,
- Xiaofeng Wen,
- Li Miao,
- Feng Lin,
- Guanxin Xu,
- Ruoyu Ma,
- Shengxia Yin,
- Zhaoyuan Hui,
- Tingting Chen,
- Shixin Guo,
- Wei Chen,
- Yingying Huang,
- Yizhi Liu,
- Jianli Wang,
- Lai Wei,
- Lie Wang
Affiliations
- Wenqiang Cao
- Institute of Immunology, Zhejiang University School of Medicine
- Jing Guo
- Institute of Immunology, Zhejiang University School of Medicine
- Xiaofeng Wen
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Li Miao
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Feng Lin
- Institute of Immunology, Zhejiang University School of Medicine
- Guanxin Xu
- Institute of Immunology, Zhejiang University School of Medicine
- Ruoyu Ma
- Institute of Immunology, Zhejiang University School of Medicine
- Shengxia Yin
- Institute of Immunology, Zhejiang University School of Medicine
- Zhaoyuan Hui
- Institute of Immunology, Zhejiang University School of Medicine
- Tingting Chen
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Shixin Guo
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Wei Chen
- Department of Biostatistics, University of Pittsburgh
- Yingying Huang
- Core Facilities, College of Medicine, Zhejiang University
- Yizhi Liu
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Jianli Wang
- Institute of Immunology, Zhejiang University School of Medicine
- Lai Wei
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Lie Wang
- Institute of Immunology, Zhejiang University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms11687
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
T cell development has been a classical model for understanding cell fate regulation by epigenetics. Here the authors show that Cxxc1 controls thymocyte development mainly through regulating several key genes, such as Rorc, Zap70 and Cd8, which requires its H3K4me3 but not DNA methylation function.
