Extruded sorghum flour (Sorghum bicolor L.) modulate adiposity and inflammation in high fat diet-induced obese rats

Priscila Marques Arbex; Maria Eliza de Castro Moreira; Renata Celi Lopes Toledo; Leandro de Morais Cardoso; Helena Maria Pinheiro-Sant'ana; Laércio dos Anjos Benjamin; Leandro Licursi; Carlos Wanderlei Piler Carvalho; Valeria Aparecida Vieira Queiroz; Hércia Stampini Duarte Martino

Journal of Functional Foods (Mar 2018)

Extruded sorghum flour (Sorghum bicolor L.) modulate adiposity and inflammation in high fat diet-induced obese rats

Priscila Marques Arbex,
Maria Eliza de Castro Moreira,
Renata Celi Lopes Toledo,
Leandro de Morais Cardoso,
Helena Maria Pinheiro-Sant'ana,
Laércio dos Anjos Benjamin,
Leandro Licursi,
Carlos Wanderlei Piler Carvalho,
Valeria Aparecida Vieira Queiroz,
Hércia Stampini Duarte Martino

Affiliations

Priscila Marques Arbex: Nutrition and Health Department, Universidade Federal de Viçosa, PH Rolfs Avenue, s/n, Viçosa, 36571-000, Minas Gerais, Brazil
Maria Eliza de Castro Moreira: Nutrition and Health Department, Universidade Federal de Viçosa, PH Rolfs Avenue, s/n, Viçosa, 36571-000, Minas Gerais, Brazil; Corresponding author.
Renata Celi Lopes Toledo: Nutrition and Health Department, Universidade Federal de Viçosa, PH Rolfs Avenue, s/n, Viçosa, 36571-000, Minas Gerais, Brazil
Leandro de Morais Cardoso: Nutrition Department, Universidade Federal de Juiz de Fora, Governador Valadares Campus, 35010-177, Governador Valadares, Minas Gerais, Brazil
Helena Maria Pinheiro-Sant'ana: Nutrition and Health Department, Universidade Federal de Viçosa, PH Rolfs Avenue, s/n, Viçosa, 36571-000, Minas Gerais, Brazil
Laércio dos Anjos Benjamin: Veterinary Department, Universidade Federal de Viçosa, PH Rolfs Avenue, s/n, Viçosa, 36571-000, Minas Gerais, Brazil
Leandro Licursi: Department of General Biology. Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Carlos Wanderlei Piler Carvalho: Embrapa Agroindústria de Alimentos, Avenida das Américas, 29501, Guaratiba, 23020-470 Rio de Janeiro, RJ, Brazil
Valeria Aparecida Vieira Queiroz: Embrapa Milho e Sorgo, Rodovia MG 424, Km 65, 35701-970 Sete Lagoas, MG, Brazil
Hércia Stampini Duarte Martino: Nutrition and Health Department, Universidade Federal de Viçosa, PH Rolfs Avenue, s/n, Viçosa, 36571-000, Minas Gerais, Brazil

Journal volume & issue: Vol. 42
pp. 346 – 355

Abstract

Read online

The aim was to determine the effect of extruded sorghum flour (ESF) on the adiposity and inflammation modulation in obese Wistar rats. Four experimental groups: normal control (AIN-93), obese control (HFD) and two tested groups (replacing 50% of cellulose and 100% of cornstarch by ESF in the HFD - HFDS50; and replacing 100% of cellulose and 100% of cornstarch by ESF in the HFD - HFDS100) were used. The luteolinidin and 5-methoxy-luteliolinidin were the main deoxyanthocianidins identified in ESF. The Lee index, percentage of adiposity, fatty acid synthase gene expression, TNF-α, blood levels of glucose and the adipocyte hypertrophy were lower in the groups treated with ESF when compared to HFD. The groups treated with ESF up-regulated the lipoprotein lipase, peroxisome proliferator activated receptor-γ gene expression and IL-10. ESF has potential as a functional food since it reduced the metabolic risk of obesity associated with adiposity and inflammation.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords