Frontiers in Bioengineering and Biotechnology (Jan 2024)

Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy

  • Chen Wang,
  • Chen Wang,
  • Shufang Ning,
  • Jinling Mai,
  • Shanyu Zhao,
  • Wenwei Jiang,
  • Junjie Pan,
  • Feifei Wu,
  • Qiuju Liu,
  • Qinle Zhang

DOI
https://doi.org/10.3389/fbioe.2024.1361347
Journal volume & issue
Vol. 12

Abstract

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Metal-organic frameworks (MOFs), with biocompatible and bio-friendly properties, exhibit intriguing potential for the drug delivery system and imaging-guided synergistic cancer theranostics. Even though tremendous attention has been attracted on MOFs-based therapeutics, which play a crucial role in therapeutic drugs, gene, and biomedical agents delivery of cancer therapy, they are often explored as simple nanocarriers without further “intelligent” functions. Herein, Fe-doped MOFs with CoP nanoparticles loading were rationally designed and synthesized for photothermal enhanced reactive oxygen species (ROS)-mediated treatment. Fe-ZIFs@CoP could generate efficient ROS through the Fenton reaction while depleting glutathione for amplifying oxidative stress. Particularly, due to the photothermal effect of Fe-ZIFs@CoP, the hyperthermia generated by as-synthesized Fe-ZIFs@CoP facilitated the advanced performance of the Fenton effect for a high amount of ROS generation. The promising “all-in-one” synergistic MOFs platform herein reported provides some prospects for future directions in this area.

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