Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

Abstract

A review of radiopaque nano and polymeric materials for atherosclerosis imaging and catheterization procedures is presented in this paper. Cardiovascular diseases (CVDs) are the leading cause of death in the US with atherosclerosis as a significant contributor for mortality and morbidity. In this review paper, we discussed the physics of radiopacity and X-ray/CT, clinically used contrast agents, and the recent progress in the development of radiopaque imaging agents and devices for the diagnosis and treatment of CVDs. We focused on radiopaque imaging agents for atherosclerosis, radiopaque embolic agents and drug eluting beads, and other radiopaque medical devices related to catheterization procedures to treat CVDs. Common strategies of introducing radiopacity in the polymers, together with examples of their applications in imaging and medical devices, are also presented. KEY WORDS: Radiopaque contrast nanoparticles and materials, X-ray, CT, Vascular diseases, Atherosclerosis, Plaque, Stenosis, Embolization, Inferior vena cava filters