Nature Communications (May 2021)
A BAFF/APRIL axis regulates obesogenic diet-driven weight gain
- Calvin C. Chan,
- Isaac T. W. Harley,
- Paul T. Pfluger,
- Aurelien Trompette,
- Traci E. Stankiewicz,
- Jessica L. Allen,
- Maria E. Moreno-Fernandez,
- Michelle S. M. A. Damen,
- Jarren R. Oates,
- Pablo C. Alarcon,
- Jessica R. Doll,
- Matthew J. Flick,
- Leah M. Flick,
- Joan Sanchez-Gurmaches,
- Rajib Mukherjee,
- Rebekah Karns,
- Michael Helmrath,
- Thomas H. Inge,
- Stuart P. Weisberg,
- Sünje J. Pamp,
- David A. Relman,
- Randy J. Seeley,
- Matthias H. Tschöp,
- Christopher L. Karp,
- Senad Divanovic
Affiliations
- Calvin C. Chan
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Isaac T. W. Harley
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Paul T. Pfluger
- Research Unit NeuroBiology of Diabetes, Helmholtz Center Munich
- Aurelien Trompette
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Traci E. Stankiewicz
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Jessica L. Allen
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Maria E. Moreno-Fernandez
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Michelle S. M. A. Damen
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Jarren R. Oates
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Pablo C. Alarcon
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Jessica R. Doll
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Matthew J. Flick
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Leah M. Flick
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Joan Sanchez-Gurmaches
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Rajib Mukherjee
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Rebekah Karns
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Michael Helmrath
- Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center
- Thomas H. Inge
- Department of Surgery, Children’s Hospital Colorado
- Stuart P. Weisberg
- Columbia University Medical Center
- Sünje J. Pamp
- Department of Microbiology and Immunology, Stanford University School of Medicine
- David A. Relman
- Department of Microbiology and Immunology, Stanford University School of Medicine
- Randy J. Seeley
- Department of Surgery, Internal Medicine and Nutritional Sciences, University of Michigan
- Matthias H. Tschöp
- Institute for Diabetes and Obesity, Helmholtz Center Munich
- Christopher L. Karp
- Department of Pediatrics, The University of Cincinnati College of Medicine
- Senad Divanovic
- Department of Pediatrics, The University of Cincinnati College of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23084-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Interactions between the immune system and adipose tissue contribute to the regulation of body weight, however, the underlying mechanisms remain incompletely understood. Here the authors dissect the role of two structurally and functionally similar immune mediators, BAFF and APRIL, in modifying diet-induced weight gain and adipocyte lipid handling.
