Effect of circuit resistance training on serum vaspin concentration and insulin resistance in patients with type 2 diabetes

Abstract

Introduction: Insulin resistance has an important role in the pathology of diabetes. Vaspin is a novel adipokine thathas a role in increase insulin sensitivity and improve glucose tolerance. There is limited information availableregarding the effect of regular exercise, particularly resistance training on serum vaspin concentrations. The purposeof this study was to investigate the effect of Circuit Resistance training on serum vaspin levels, Insulin resistanceand its relation In adult men with type 2 diabetes. Methods: 18 adult men with type 2 diabetes (age: 48.50±7.73 yr,weight: 79.41±12.60 kg) were randomly assigned to experimental (n= 10) and control (n= 8) groups. Experimentalgroup participated in a resistance training program (3 days a week for 8 weeks) with an intensity of 50 to 80% ofone repetition maximum. Blood samples collected in the 12-hour fasting state before and after training period andlevels of vaspin, insulin, glucose and insulin resistance index (HOMA-IR) were measured by ELISA method. Afterevaluating variables and statistical analysis with t- test, It was found that: Results: After a 8 week resistancetraining, levels of glucose, insulin and insulin resistance index (HOMA-IR) were significantly decreased (P= 0.040,0.012 and 0.011, respectively). Whereas, serum vaspin concentration showed no significant changes in resistancetrained group when compared with their control groups (p=0/380). Also, no significant correlation between Serumvaspin concentration and levels of glucose, insulin and HOMA-IR were observed between the two groups.Conclusion: The results of the present study suggest that circuit resistance training can be used as an effective factorin improving of insulin sensitivity in type 2 diabetic patients.

Keywords

• diabetes mellitus
• vaspin
• circuit resistance training