REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway

Huairong Zhang; Andrea Liliam Gomez Corredor; Julia Messina-Pacheco; Qing Li; George Zogopoulos; Nancy Kaddour; Yifan Wang; Bing-yin Shi; Alex Gregorieff; Jun-li Liu; Zu-hua Gao

doi:10.1038/s42003-021-02193-z

Communications Biology (Jun 2021)

REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway

Huairong Zhang,
Andrea Liliam Gomez Corredor,
Julia Messina-Pacheco,
Qing Li,
George Zogopoulos,
Nancy Kaddour,
Yifan Wang,
Bing-yin Shi,
Alex Gregorieff,
Jun-li Liu,
Zu-hua Gao

Affiliations

Huairong Zhang: Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Andrea Liliam Gomez Corredor: Department of Pathology, McGill University and the Research Institute of McGill University Health Centre
Julia Messina-Pacheco: Department of Pathology, McGill University and the Research Institute of McGill University Health Centre
Qing Li: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC)
George Zogopoulos: Department of Surgery, McGill University and the Research Institute of McGill University Health Centre
Nancy Kaddour: Department of Medicine, McGill University and the Research Institute of McGill University Health Centre
Yifan Wang: Department of Surgery, McGill University and the Research Institute of McGill University Health Centre
Bing-yin Shi: Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University
Alex Gregorieff: Department of Pathology, McGill University and the Research Institute of McGill University Health Centre
Jun-li Liu: Department of Medicine, McGill University and the Research Institute of McGill University Health Centre
Zu-hua Gao: Department of Pathology, McGill University and the Research Institute of McGill University Health Centre

DOI: https://doi.org/10.1038/s42003-021-02193-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Using several human and murine models, Zhang et al discover a role for the REG3A/REG3B proteins in acinar to ductal metaplasia (ADM), a precursor of pancreatic ductal adenocarcinoma (PDAC). They find that REG3B induces ADM through RAS-RAF-MEK-ERK signaling and identify EXTL3 as a REG3B receptor, providing new insights into PDAC development.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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