Nature Communications (Oct 2022)

Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda

  • Patrick K. Tumwebaze,
  • Melissa D. Conrad,
  • Martin Okitwi,
  • Stephen Orena,
  • Oswald Byaruhanga,
  • Thomas Katairo,
  • Jennifer Legac,
  • Shreeya Garg,
  • David Giesbrecht,
  • Sawyer R. Smith,
  • Frida G. Ceja,
  • Samuel L. Nsobya,
  • Jeffrey A. Bailey,
  • Roland A. Cooper,
  • Philip J. Rosenthal

DOI
https://doi.org/10.1038/s41467-022-33873-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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In this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have emerged, compared to eastern Uganda.