Preparation and Slow-release Properties of Nanocellulose Composite Hydrogels
Kehong Zhang,
Xingyu Guo,
Yue Zhang,
Minyi Wang,
Wenqi Zhang
Affiliations
Kehong Zhang
Anhui Engineering Research Center for Highly Functional Fiber Products for Automobiles, College of Materials and Chemistry, Anhui Agricultural University, Hefei, Anhui 230036, China; Fujian Provincial Key Lab of Coastal Basin Environment, Fujian Polytechnic Normal University, Fuqing, Fujian 350300 China
Xingyu Guo
Anhui Engineering Research Center for Highly Functional Fiber Products for Automobiles, College of Materials and Chemistry, Anhui Agricultural University, Hefei, Anhui 230036, China
Yue Zhang
Anhui Engineering Research Center for Highly Functional Fiber Products for Automobiles, College of Materials and Chemistry, Anhui Agricultural University, Hefei, Anhui 230036, China
Minyi Wang
Anhui Engineering Research Center for Highly Functional Fiber Products for Automobiles, College of Materials and Chemistry, Anhui Agricultural University, Hefei, Anhui 230036, China
Wenqi Zhang
Anhui Engineering Research Center for Highly Functional Fiber Products for Automobiles, College of Materials and Chemistry, Anhui Agricultural University, Hefei, Anhui 230036, China
Nanocellulose (CNF) was obtained from carrots using a combination of chemical treatment, mechanical milling, and ultrasonic treatment. Ultrafast preparation of maleic anhydride esterified nanocellulose was achieved by a hydrated hydrogen ion-driven dissociation, chemical cross-linking strategy based on a “one-pot” reaction method. Esterification modification with maleic anhydride reduced the crystallinity of nanocellulose and enhanced its thermal stability. High-strength drug-carrying hydrogels (MACNF/SA) with different drug loading capacities were prepared using cefixime (CFX) as a drug model and maleic anhydride esterified nanocellulose (MACNF) and sodium alginate (SA) as the main raw materials. The compressive strength of MACNF/SA hydrogels made from MACNF reached a maximum of 80.3 kPa when the mass ratio of CNF to MA was 2.5:12. Rheological property tests showed that the MACNF/SA hydrogels were pseudoplastic fluids with shear thinning. The drug release from the drug-carrying hydrogels followed non-Fickian diffusion.
