Communications Biology (Apr 2023)
A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation
- Waka Sato,
- Miho Watanabe-Takahashi,
- Takuya Murata,
- Naoko Utsunomiya-Tate,
- Jun Motoyama,
- Masataka Anzai,
- Seiko Ishihara,
- Nanako Nishioka,
- Hina Uchiyama,
- Juri Togashi,
- Saeka Nishihara,
- Kiyoshi Kawasaki,
- Takashi Saito,
- Takaomi C. Saido,
- Satoru Funamoto,
- Kiyotaka Nishikawa
Affiliations
- Waka Sato
- Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University
- Miho Watanabe-Takahashi
- Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University
- Takuya Murata
- Faculty of Pharma-Science, Teikyo University
- Naoko Utsunomiya-Tate
- Faculty of Pharma-Science, Teikyo University
- Jun Motoyama
- Laboratory of Developmental Neurobiology, Graduate School of Brain Science, Doshisha University
- Masataka Anzai
- Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University
- Seiko Ishihara
- Department of Neuropathology, Graduate School of Life and Medical Sciences, Doshisha University
- Nanako Nishioka
- Department of Neuropathology, Graduate School of Life and Medical Sciences, Doshisha University
- Hina Uchiyama
- Department of Neuropathology, Graduate School of Life and Medical Sciences, Doshisha University
- Juri Togashi
- Department of Neuropathology, Graduate School of Life and Medical Sciences, Doshisha University
- Saeka Nishihara
- Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts
- Kiyoshi Kawasaki
- Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts
- Takashi Saito
- Department of Neurocognitive Science, Institute of Brain Science, Graduate School of Medical Sciences, Nagoya City University
- Takaomi C. Saido
- Laboratory for Proteolytic Neuroscience, Riken Center For Brain Science
- Satoru Funamoto
- Department of Neuropathology, Graduate School of Life and Medical Sciences, Doshisha University
- Kiyotaka Nishikawa
- Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University
- DOI
- https://doi.org/10.1038/s42003-023-04771-9
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 13
Abstract
Multivalent peptide library screens identify a tetravalent peptide that binds APP and A β via multivalent interactions and reduces A β in the brains of Alzheimer’s disease model mice.
