Frontiers in Pediatrics (Jul 2022)
Current therapy option for necrotizing enterocolitis: Practicalities and challenge
- Huihuan Wu,
- Huihuan Wu,
- Kehang Guo,
- Kehang Guo,
- Zewei Zhuo,
- Zewei Zhuo,
- Ruijie Zeng,
- Ruijie Zeng,
- Yujun Luo,
- Qi Yang,
- Jingwei Li,
- Rui Jiang,
- Rui Jiang,
- Zena Huang,
- Weihong Sha,
- Weihong Sha,
- Hao Chen,
- Hao Chen
Affiliations
- Huihuan Wu
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Huihuan Wu
- School of Medicine, South China University of Technology, Guangzhou, China
- Kehang Guo
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Kehang Guo
- School of Medicine, South China University of Technology, Guangzhou, China
- Zewei Zhuo
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Zewei Zhuo
- School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China
- Ruijie Zeng
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Ruijie Zeng
- Shantou University Medical College, Shantou, China
- Yujun Luo
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Qi Yang
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Jingwei Li
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Rui Jiang
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Rui Jiang
- School of Medicine, South China University of Technology, Guangzhou, China
- Zena Huang
- Department of General Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Weihong Sha
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Weihong Sha
- School of Medicine, South China University of Technology, Guangzhou, China
- Hao Chen
- Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
- Hao Chen
- School of Medicine, South China University of Technology, Guangzhou, China
- DOI
- https://doi.org/10.3389/fped.2022.954735
- Journal volume & issue
-
Vol. 10
Abstract
Necrotizing enterocolitis (NEC) is one of the most prevalent neonatal gastrointestinal disorders. Despite ongoing breakthroughs in its treatment and prevention, the incidence and mortality associated with NEC remain high. New therapeutic approaches, such as breast milk composition administration, stem cell therapy, immunotherapy, and fecal microbiota transplantation (FMT) have recently evolved the prevention and the treatment of NEC. This study investigated the most recent advances in NEC therapeutic approaches and discussed their applicability to bring new insight to NEC treatment.
Keywords
- necrotizing enterocolitis
- breast milk composition
- stem cell
- fecal microbiota transplantation
- immunotherapy
