Frontiers in Aging Neuroscience (Dec 2022)
Role of angiotensin II in aging
- Wenmin Yi,
- Wenmin Yi,
- Wenmin Yi,
- Wenmin Yi,
- Wenmin Yi,
- Fei Chen,
- Fei Chen,
- Fei Chen,
- Fei Chen,
- Fei Chen,
- Huiji Zhang,
- Huiji Zhang,
- Huiji Zhang,
- Huiji Zhang,
- Peng Tang,
- Peng Tang,
- Minghao Yuan,
- Minghao Yuan,
- Minghao Yuan,
- Minghao Yuan,
- Minghao Yuan,
- Jie Wen,
- Jie Wen,
- Shengyuan Wang,
- Shengyuan Wang,
- Shengyuan Wang,
- Shengyuan Wang,
- Shengyuan Wang,
- Zhiyou Cai,
- Zhiyou Cai,
- Zhiyou Cai,
- Zhiyou Cai,
- Zhiyou Cai
Affiliations
- Wenmin Yi
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Wenmin Yi
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Wenmin Yi
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Wenmin Yi
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Wenmin Yi
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Fei Chen
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Fei Chen
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Fei Chen
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Fei Chen
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Fei Chen
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Huiji Zhang
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Huiji Zhang
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Huiji Zhang
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Huiji Zhang
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Peng Tang
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Peng Tang
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Minghao Yuan
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Minghao Yuan
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Minghao Yuan
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Minghao Yuan
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Minghao Yuan
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Jie Wen
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Jie Wen
- Department and Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong, China
- Shengyuan Wang
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Shengyuan Wang
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Shengyuan Wang
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Shengyuan Wang
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Shengyuan Wang
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Zhiyou Cai
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Zhiyou Cai
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Zhiyou Cai
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Zhiyou Cai
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Zhiyou Cai
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- DOI
- https://doi.org/10.3389/fnagi.2022.1002138
- Journal volume & issue
-
Vol. 14
Abstract
Aging is an inevitable progressive decline in physiological organ function that increases the chance of disease and death. The renin–angiotensin system (RAS) is involved in the regulation of vasoconstriction, fluid homeostasis, cell growth, fibrosis, inflammation, and oxidative stress. In recent years, unprecedented advancement has been made in the RAS study, particularly with the observation that angiotensin II (Ang II), the central product of the RAS, plays a significant role in aging and chronic disease burden with aging. Binding to its receptors (Ang II type 1 receptor – AT1R in particular), Ang II acts as a mediator in the aging process by increasing free radical production and, consequently, mitochondrial dysfunction and telomere attrition. In this review, we examine the physiological function of the RAS and reactive oxygen species (ROS) sources in detail, highlighting how Ang II amplifies or drives mitochondrial dysfunction and telomere attrition underlying each hallmark of aging and contributes to the development of aging and age-linked diseases. Accordingly, the Ang II/AT1R pathway opens a new preventive and therapeutic direction for delaying aging and reducing the incidence of age-related diseases in the future.
Keywords
