Potentiating antibiotic efficacy via perturbation of non-essential gene expression

Peter B. Otoupal; Kristen A. Eller; Keesha E. Erickson; Jocelyn Campos; Thomas R. Aunins; Anushree Chatterjee

doi:10.1038/s42003-021-02783-x

Communications Biology (Nov 2021)

Potentiating antibiotic efficacy via perturbation of non-essential gene expression

Peter B. Otoupal,
Kristen A. Eller,
Keesha E. Erickson,
Jocelyn Campos,
Thomas R. Aunins,
Anushree Chatterjee

Affiliations

Peter B. Otoupal: Department of Chemical and Biological Engineering, University of Colorado at Boulder
Kristen A. Eller: Department of Chemical and Biological Engineering, University of Colorado at Boulder
Keesha E. Erickson: Department of Chemical and Biological Engineering, University of Colorado at Boulder
Jocelyn Campos: Department of Chemical and Biological Engineering, University of Colorado at Boulder
Thomas R. Aunins: Department of Chemical and Biological Engineering, University of Colorado at Boulder
Anushree Chatterjee: Department of Chemical and Biological Engineering, University of Colorado at Boulder

DOI: https://doi.org/10.1038/s42003-021-02783-x
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Otoupal et al. use a systematic approach to investigate the effects of fitness neutral gene perturbations and antibiotic synergy in Escherichia coli. These neutral fitness interactions worked as co-therapies in a Salmonella enterica infection and informed the design of re-sensitization therapies in multi-drug resistant E. coli and Klebisiella pneumoniae clinical isolates.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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