Cytokine Synthesis by Chondroblastoma: Relation to Local Inflammation

Abstract

Purpose. To investigate cytokine production by chondroblastoma in inducing local inflammation and adjacent-joint arthritis. Methods. Immunohistochemical analyses of curetted tissues using anti-human interleukin (IL)-1β, IL-6, IL-8, and tumour necrosis factor (TNF)-α were performed for 6 patients with chondroblastoma and 3 patients with giant cell tumour (GCT) of bone. In addition, prostaglandin E 2 , IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, and TNF-α in the cyst fluid of one of the patients with chondroblastoma and 2 with GCT of bone were measured using immunoassay kits. Conclusion. Cytokines such as IL-1β, IL-8, TNF-α, and particularly IL-6 play an important role in local inflammation in patients with chondroblastoma.