Journal of Inflammation Research (Sep 2023)
The Emerging Roles of Ferroptosis in Pathophysiology and Treatment of Acute Lung Injury
Abstract
Yufei Wang,1,2,* Zijun Zhao,2,3,* Zhaoyang Xiao1,2 1Department of Anesthesiology, The Second Affiliated Hospital of Dalian Medical University, Dalian City, Liaoning Province, People’s Republic of China; 2School of Graduates, Dalian Medical University, Dalian, Liaoning Province, People’s Republic of China; 3Department of Anesthesiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou City, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaoyang Xiao, Department of Anesthesiology, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian, Liaoning Province, 116027, People’s Republic of China, Email [email protected]: Ferroptosis, a programmed cell death discovered in recent years, is an iron-dependent lipid peroxidation accumulation. Unlike other modes of cell death (autophagy, necroptosis, pyroptosis, cuproptosis, etc.), ferroptosis has unique morphological characteristics and plays an important role in a variety of diseases. In recent years, there has been great progress in the study of ferroptosis. Studies have found that ferroptosis is associated with acute lung injury (ALI), a condition with a high mortality rate and limited treatment options. This paper summarizes the mechanism of ferroptosis from the perspectives of iron metabolism, lipid metabolism, amino acid metabolism, and glutathione metabolism. It also discusses the research progress of ferroptosis in ALI in order to find new directions for the prevention and treatment of this condition.Keywords: ferroptosis, acute lung injury, ischemia, sepsis, targeted therapy
