Dermatologica Sinica (Sep 2014)

Ticlopidine-induced subacute cutaneous lupus erythematosus: A case report and literature review

  • Yi-Ching Chen,
  • Yu-Hung Wu

DOI
https://doi.org/10.1016/j.dsi.2014.01.001
Journal volume & issue
Vol. 32, no. 3
pp. 183 – 186

Abstract

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Many drugs have been reported to induce lupus in a minority of patients. Ticlopidine hydrochloride inhibits platelet aggregation and is widely used for the prevention of thrombosis. There have been only a few reports of ticlopidine-induced lupus. Here, we review 13 previously reported cases and describe the case of a 71-year-old man with ticlopidine-induced subacute cutaneous lupus erythematosus. His diagnosis was supported by the appearance of papulosquamous skin lesions on sun-exposed areas and detectable anti-Ro/SS-A antibodies, shortly after drug initiation as well as the gradual resolution of these symptoms after the discontinuation of ticlopidine. Our case highlights that when a patient presents with subacute cutaneous lupus erythematosus-like skin lesions, ticlopidine should be considered as a potential causative agent.

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