Nature Communications (Feb 2021)

Comprehensive analysis of single cell ATAC-seq data with SnapATAC

  • Rongxin Fang,
  • Sebastian Preissl,
  • Yang Li,
  • Xiaomeng Hou,
  • Jacinta Lucero,
  • Xinxin Wang,
  • Amir Motamedi,
  • Andrew K. Shiau,
  • Xinzhu Zhou,
  • Fangming Xie,
  • Eran A. Mukamel,
  • Kai Zhang,
  • Yanxiao Zhang,
  • M. Margarita Behrens,
  • Joseph R. Ecker,
  • Bing Ren

DOI
https://doi.org/10.1038/s41467-021-21583-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Single cell analysis of transposase-accessible chromatin is deepening our understanding on the origins of cellular diversity, yet methods are limited by data sparsity. Here, the authors introduce SnapATAC, a pipeline to resolve cellular heterogeneity and reveal candidate regulatory elements across different cell populations.