Nature Communications (Jul 2021)

Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging

  • Xavier Rovira-Clavé,
  • Sizun Jiang,
  • Yunhao Bai,
  • Bokai Zhu,
  • Graham Barlow,
  • Salil Bhate,
  • Ahmet F. Coskun,
  • Guojun Han,
  • Chin-Min Kimmy Ho,
  • Chuck Hitzman,
  • Shih-Yu Chen,
  • Felice-Alessio Bava,
  • Garry P. Nolan

DOI
https://doi.org/10.1038/s41467-021-24822-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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Multiplexed ion beam imaging can provide subcellular localisation information but with limited resolution. Here the authors report an ion beam imaging method with nanoscale resolution which they use to assess the subcellular distribution of cisplatin.