Polydioxanone Membrane Compared with Collagen Membrane for Bone Regeneration
Lilian Caldas Quirino,
Pedro Henrique de Azambuja Carvalho,
Renato Torres Augusto Neto,
Cássio Amaro Comachio,
Naara Gabriela Monteiro,
Ana Cláudia Ervolino-Silva,
Roberta Okamoto,
Valfrido Antonio Pereira-Filho
Affiliations
Lilian Caldas Quirino
Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Rua Humaitá 1680, Araraquara CEP 14801-903, SP, Brazil
Pedro Henrique de Azambuja Carvalho
Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Rua Humaitá 1680, Araraquara CEP 14801-903, SP, Brazil
Renato Torres Augusto Neto
Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Rua Humaitá 1680, Araraquara CEP 14801-903, SP, Brazil
Cássio Amaro Comachio
Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Rua Humaitá 1680, Araraquara CEP 14801-903, SP, Brazil
Naara Gabriela Monteiro
Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba CEP 16015-050, SP, Brazil
Ana Cláudia Ervolino-Silva
Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba CEP 16015-050, SP, Brazil
Roberta Okamoto
Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba CEP 16015-050, SP, Brazil
Valfrido Antonio Pereira-Filho
Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Rua Humaitá 1680, Araraquara CEP 14801-903, SP, Brazil
Guided bone regeneration (GBR) is an approach that induces osteopromotion through the regenerative membranes. These barriers exhibit bioactive behavior and mechanical function. Polydioxanone is a synthetic option, already used in medicine and dentistry, with good results in bone regeneration. This study aimed to evaluate bone repair in critical defects in rat calvaria using a polydioxanone membrane (Plenum® Guide) compared with a commercially available collagen-based membrane (Bio-Gide®). The bone defects were filled with Plenum® Osshp, a synthetic bone graft, hydroxyapatite:β-tricalcium phosphate, 70:30%, Group PG (Plenum® Guide + Plenum® Osshp), and Group BG (Geistlich Bio-Gide® + Plenum® Osshp). The specimens were submitted to immunohistochemical (RUNX2 and OPN), gene expression (RUNX2, IBSP, and VEGF), histometric, and microtomography analyses after 07, 15, 30, and 60 days postoperative. PG group showed greater immunolabeling area for RUNX2 and OPN, higher gene expression of VEGF (3.15 ± 0.85), and IBSP (24.9 ± 0.59). However, there was no statistical difference between groups in the histometric analysis regarding the percentage of connective tissue PG (0.83 ± 0.45), BG (0.70 ± 0.34), neoformed bone PG (0.60 ± 0.4), BG (0.65 ± 0.51), and remaining biomaterial PG (0.84 ± 0.31), BG (0.91 ± 0.33). In addition, there was no statistical difference between groups by micro-CT analysis. The absorbable-synthetic membrane, Plenum® Guide, is an effective membrane for guided bone regeneration.
