Nature Communications (Aug 2019)

Structural basis for delta cell paracrine regulation in pancreatic islets

  • Rafael Arrojo e Drigo,
  • Stefan Jacob,
  • Concha F. García-Prieto,
  • Xiaofeng Zheng,
  • Masahiro Fukuda,
  • Hoa Tran Thi Nhu,
  • Olga Stelmashenko,
  • Flavia Letícia Martins Peçanha,
  • Rayner Rodriguez-Diaz,
  • Eric Bushong,
  • Thomas Deerinck,
  • Sebastien Phan,
  • Yusuf Ali,
  • Ingo Leibiger,
  • Minni Chua,
  • Thomas Boudier,
  • Sang-Ho Song,
  • Martin Graf,
  • George J. Augustine,
  • Mark H. Ellisman,
  • Per-Olof Berggren

DOI
https://doi.org/10.1038/s41467-019-11517-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approaches.