NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice

Yoshitaka Murakami; Fan-Yan Wei; Yoshimi Kawamura; Haruki Horiguchi; Tsuyoshi Kadomatsu; Keishi Miyata; Kyoko Miura; Yuichi Oike; Yukio Ando; Mitsuharu Ueda; Kazuhito Tomizawa; Takeshi Chujo

doi:10.1038/s42003-023-04680-x

Communications Biology (Mar 2023)

NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice

Yoshitaka Murakami,
Fan-Yan Wei,
Yoshimi Kawamura,
Haruki Horiguchi,
Tsuyoshi Kadomatsu,
Keishi Miyata,
Kyoko Miura,
Yuichi Oike,
Yukio Ando,
Mitsuharu Ueda,
Kazuhito Tomizawa,
Takeshi Chujo

Affiliations

Yoshitaka Murakami: Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University
Fan-Yan Wei: Department of Modomics Biology and Medicine, Institute of Development, Aging and Cancer, Tohoku University
Yoshimi Kawamura: Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
Haruki Horiguchi: Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University
Tsuyoshi Kadomatsu: Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University
Keishi Miyata: Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University
Kyoko Miura: Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University
Yuichi Oike: Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University
Yukio Ando: Department of Amyloidosis Research, Faculty of Pharmaceutical Sciences, Nagasaki International University
Mitsuharu Ueda: Department of Neurology, Faculty of Life Sciences, Kumamoto University
Kazuhito Tomizawa: Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University
Takeshi Chujo: Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University

DOI: https://doi.org/10.1038/s42003-023-04680-x
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

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A mitochondrial tRNA modification enzyme, NSUN3, is found to be essential for embryonic development in mice, with whole-body knockout causing embryonic lethality and heart-specific Nsun3 knockout leading to heart aberration in older mice.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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