Facing Cell Autophagy in Gastric Cancer – What Do We Know so Far?

Abstract

Ting Xiu,1,2 Qie Guo,1 Fan-Bo Jing1 1Department of Clinical Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, People’s Republic of China; 2Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, 266021, People’s Republic of ChinaCorrespondence: Fan-Bo Jing Email [email protected]: Autophagy is a process by which misfolded proteins and damaged organelles in the lysosomes of tumor cells were degraded reusing decomposed substances and avoiding accumulation of large amounts of harmful substances. Here, the role of autophagy in the development of malignant transformation of gastric tumors, and the underlying mechanisms involved in autophagy formation, and the application of targeted autophagy in the treatment of gastric cancer were summarized.Keywords: autophagy, gastric cancer, autophagy-related genes, lysosomes, targeted therapy

Keywords

• autophagy;gastric cancer;autophagy-related genes;lysosomes;targeted therapy