Presence of Akkermansiaceae in gut microbiome and immunotherapy effectiveness in patients with advanced non-small cell lung cancer

Anna Grenda; Ewelina Iwan; Izabela Chmielewska; Paweł Krawczyk; Aleksandra Giza; Arkadiusz Bomba; Małgorzata Frąk; Anna Rolska; Michał Szczyrek; Robert Kieszko; Tomasz Kucharczyk; Bożena Jarosz; Dariusz Wasyl; Janusz Milanowski

doi:10.1186/s13568-022-01428-4

AMB Express (Jul 2022)

Presence of Akkermansiaceae in gut microbiome and immunotherapy effectiveness in patients with advanced non-small cell lung cancer

Anna Grenda,
Ewelina Iwan,
Izabela Chmielewska,
Paweł Krawczyk,
Aleksandra Giza,
Arkadiusz Bomba,
Małgorzata Frąk,
Anna Rolska,
Michał Szczyrek,
Robert Kieszko,
Tomasz Kucharczyk,
Bożena Jarosz,
Dariusz Wasyl,
Janusz Milanowski

Affiliations

Anna Grenda: Department of Pneumonology, Oncology and Allergology, Medical University of Lublin
Ewelina Iwan: Department of Omics Analyses, National Veterinary Research Institute
Izabela Chmielewska: Department of Pneumonology, Oncology and Allergology, Medical University of Lublin
Paweł Krawczyk: Department of Pneumonology, Oncology and Allergology, Medical University of Lublin
Aleksandra Giza: Department of Omics Analyses, National Veterinary Research Institute
Arkadiusz Bomba: Department of Omics Analyses, National Veterinary Research Institute
Małgorzata Frąk: Department of Pneumonology, Oncology and Allergology, Medical University of Lublin
Anna Rolska: Department of Pneumonology, Oncology and Allergology, Medical University of Lublin
Michał Szczyrek: Department of Pneumonology, Oncology and Allergology, Medical University of Lublin
Robert Kieszko: Department of Pneumonology, Oncology and Allergology, Medical University of Lublin
Tomasz Kucharczyk: Department of Pneumonology, Oncology and Allergology, Medical University of Lublin
Bożena Jarosz: Chair and Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin
Dariusz Wasyl: Department of Omics Analyses, National Veterinary Research Institute
Janusz Milanowski: Department of Pneumonology, Oncology and Allergology, Medical University of Lublin

DOI: https://doi.org/10.1186/s13568-022-01428-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 7

Abstract

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Key points Composition of the microbiome can influence patients response to immunotherapy Response to immunotherapy of NSCLC patients is associated with the presence of Akkermansiaceae in the gut Akkermansia could be used as a predictor for patient treated with immunological checkpoint inhibitors

Published in AMB Express

ISSN: 2191-0855 (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Microbiology
Website: http://www.amb-express.com/

About the journal

Abstract

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