Revista da Sociedade Brasileira de Medicina Tropical (Dec 2003)

Avaliação hematológica e histopatológica de camundongos BALB/c e C57BL/6 expostos aos antígenos recombinantes Cytoplasmic Repetitive Antigen e Flagellar Repetitive Antigen de Trypanosoma cruzi Hematological and histopathological evaluation of BALB/c and C57BL/6 mice exposed to Cytoplasmic Repetitive Antigen and Flagellar Repetitive Antigen recombinant antigens of Trypanosoma cruzi

  • Valéria Rêgo Alves Pereira,
  • Virginia Maria Barros de Lorena,
  • Ana Paula Galvão-da Silva,
  • Mineo Nakazawa,
  • Edimilson Domingos da Silva,
  • Antonio Gomes Pinto Ferreira,
  • Ulisses Montarroyos,
  • Eridan de Medeiros Coutinho,
  • Yara de Miranda Gomes

DOI
https://doi.org/10.1590/S0037-86822003000600016
Journal volume & issue
Vol. 36, no. 6
pp. 739 – 742

Abstract

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Os antígenos recombinantes Cytoplasmic Repetitive Antigen e Flagellar Repetitive Antigen de Trypanosoma cruzi foram inoculados em camundongos BALB/c e C57BL/6 e o seu efeito avaliado a nível hematológico e histopatológico. Os resultados mostraram que o padrão histológico normal dos órgãos e o perfil hematológico dos camundongos não foram modificados sugerindo que esses antígenos não parecem causar dano ao animal.The Cytoplasmic Repetitive Antigen and Flagellar Repetitive Antigen recombinant antigens of Trypanosoma cruzi were inoculated into BALB/c and C57BL/6 mice and its effects evaluated at hematological and histopathological levels. The results showed that the histological pattern of the organs and the hematological profile of mice were not modified suggesting that these antigens are not harmful for the animal.

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