Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

Michael Landreh; Erik G. Marklund; Povilas Uzdavinys; Matteo T. Degiacomi; Mathieu Coincon; Joseph Gault; Kallol Gupta; Idlir Liko; Justin L. P. Benesch; David Drew; Carol V. Robinson

doi:10.1038/ncomms13993

Nature Communications (Jan 2017)

Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

Michael Landreh,
Erik G. Marklund,
Povilas Uzdavinys,
Matteo T. Degiacomi,
Mathieu Coincon,
Joseph Gault,
Kallol Gupta,
Idlir Liko,
Justin L. P. Benesch,
David Drew,
Carol V. Robinson

Affiliations

Michael Landreh: Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford
Erik G. Marklund: Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford
Povilas Uzdavinys: Department of Biochemistry and Biophysics, Centre for Biomembrane Research, Stockholm University
Matteo T. Degiacomi: Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford
Mathieu Coincon: Department of Biochemistry and Biophysics, Centre for Biomembrane Research, Stockholm University
Joseph Gault: Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford
Kallol Gupta: Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford
Idlir Liko: Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford
Justin L. P. Benesch: Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford
David Drew: Department of Biochemistry and Biophysics, Centre for Biomembrane Research, Stockholm University
Carol V. Robinson: Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford

DOI: https://doi.org/10.1038/ncomms13993
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

Read online

Na+/H+antiporters transport sodium or lithium ions across the membrane in exchange for protons. Here the authors combine ion mobility mass spectrometry and molecular dynamics simulations to uncover a facilitating role for lipids in the transport mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal