Nature Communications (Feb 2018)

Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast

  • Diego J. Páez-Moscoso,
  • Lili Pan,
  • Rutendo F. Sigauke,
  • Morgan R. Schroeder,
  • Wen Tang,
  • Peter Baumann

DOI
https://doi.org/10.1038/s41467-017-02284-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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The core of the telomerase holoenzyme is composed of the reverse transcriptase and the non-coding RNA template. Here the authors identify Pof8 as a new constitutive component of fission yeast telomerase, loss of which causes telomerase assembly defects and critically short telomeres.