miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

Mitsuo Kato; Maryam Abdollahi; Ragadeepthi Tunduguru; Walter Tsark; Zhuo Chen; Xiwei Wu; Jinhui Wang; Zhen Bouman Chen; Feng-Mao Lin; Linda Lanting; Mei Wang; Janice Huss; Patrick T Fueger; David Chan; Rama Natarajan

doi:10.1038/s42003-020-01516-w

Communications Biology (Jan 2021)

miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

Mitsuo Kato,
Maryam Abdollahi,
Ragadeepthi Tunduguru,
Walter Tsark,
Zhuo Chen,
Xiwei Wu,
Jinhui Wang,
Zhen Bouman Chen,
Feng-Mao Lin,
Linda Lanting,
Mei Wang,
Janice Huss,
Patrick T Fueger,
David Chan,
Rama Natarajan

Affiliations

Mitsuo Kato: Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Caltech
Maryam Abdollahi: Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Caltech
Ragadeepthi Tunduguru: Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Caltech
Walter Tsark: Transgenic Mouse Facility, Center for Comparative Medicine, Caltech
Zhuo Chen: Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Caltech
Xiwei Wu: Integrative Genomics Core, Caltech
Jinhui Wang: Integrative Genomics Core, Caltech
Zhen Bouman Chen: Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Caltech
Feng-Mao Lin: Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Caltech
Linda Lanting: Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Caltech
Mei Wang: Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Caltech
Janice Huss: Department of Cellular and Molecular Endocrinology, Caltech
Patrick T Fueger: Department of Cellular and Molecular Endocrinology, Caltech
David Chan: Division of Biology and Biological Engineering, Caltech
Rama Natarajan: Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Caltech

DOI: https://doi.org/10.1038/s42003-020-01516-w
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 17

Abstract

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Kato, Abdollahi et al. identify a redox protein thioredoxin and mitochondrial fission-1 (FIS1) protein as miR-379 targets in mouse kidney. They find that miR-379 knockout mice are protected from diabetic kidney disease by enhancing mitophagy via FIS1, suggesting miR-379 as a potential therapeutic target for diabetic kidney disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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