Clinical and Translational Radiation Oncology (Jan 2018)

SYSTEMS-2: A randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma

  • M. Ashton,
  • N. O'Rourke,
  • N. Macleod,
  • B. Laird,
  • J. Stobo,
  • C. Kelly,
  • L. Alexander,
  • K. Franks,
  • K. Moore,
  • S. Currie,
  • R. Valentine,
  • A.J. Chalmers

DOI
https://doi.org/10.1016/j.ctro.2017.11.004
Journal volume & issue
Vol. 8, no. C
pp. 45 – 49

Abstract

Read online

SYSTEMS-2 is a randomised study of radiotherapy dose escalation for pain control in 112 patients with malignant pleural mesothelioma (MPM). Standard palliative (20 Gy/5#) or dose escalated treatment (36 Gy/6#) will be delivered using advanced radiotherapy techniques and pain responses will be compared at week 5. Data will guide optimal palliative radiotherapy in MPM.