Nature Communications (Sep 2018)
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
- Yuan Zhao,
- Mohamed Uduman,
- Jacqueline H. Y. Siu,
- Thomas J. Tull,
- Jeremy D. Sanderson,
- Yu-Chang Bryan Wu,
- Julian Q. Zhou,
- Nedyalko Petrov,
- Richard Ellis,
- Katrina Todd,
- Konstantia-Maria Chavele,
- William Guesdon,
- Anna Vossenkamper,
- Wayel Jassem,
- David P. D’Cruz,
- David J. Fear,
- Susan John,
- Dagmar Scheel-Toellner,
- Claire Hopkins,
- Estefania Moreno,
- Natalie L. Woodman,
- Francesca Ciccarelli,
- Susanne Heck,
- Steven H. Kleinstein,
- Mats Bemark,
- Jo Spencer
Affiliations
- Yuan Zhao
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- Mohamed Uduman
- Department of Pathology, Yale University School of Medicine
- Jacqueline H. Y. Siu
- Department of Surgery, University of Cambridge
- Thomas J. Tull
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- Jeremy D. Sanderson
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- Yu-Chang Bryan Wu
- Randall Division of Cell and Molecular Biophysics, King’s College London
- Julian Q. Zhou
- Interdepartmental Program in Computational Biology and Bioinformatics, Yale University
- Nedyalko Petrov
- Biomedical Research Centre, Guy’s and St. Thomas’ NHS Trust
- Richard Ellis
- Biomedical Research Centre, Guy’s and St. Thomas’ NHS Trust
- Katrina Todd
- Biomedical Research Centre, Guy’s and St. Thomas’ NHS Trust
- Konstantia-Maria Chavele
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- William Guesdon
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- Anna Vossenkamper
- Barts & The London School of Medicine and Dentistry, Blizard Institute, Whitechapel
- Wayel Jassem
- Liver Transplant Unit, Institute of Liver Studies, King’s College Hospital, Denmark Hill
- David P. D’Cruz
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- David J. Fear
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- Susan John
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- Dagmar Scheel-Toellner
- Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham
- Claire Hopkins
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- Estefania Moreno
- Barts & The London School of Medicine and Dentistry, Blizard Institute, Whitechapel
- Natalie L. Woodman
- School of Cancer Sciences, King’s College London, Guy’s Campus
- Francesca Ciccarelli
- School of Cancer Sciences, King’s College London, Guy’s Campus
- Susanne Heck
- Biomedical Research Centre, Guy’s and St. Thomas’ NHS Trust
- Steven H. Kleinstein
- Department of Pathology, Yale University School of Medicine
- Mats Bemark
- Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
- Jo Spencer
- School of Immunology and Microbial Sciences, King’s College London, Guy’s Campus
- DOI
- https://doi.org/10.1038/s41467-018-06089-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear. Here the authors use mass cytometry and sequential clustering methods to show that, despite their shared features, memory and marginal zone B cells represent distinct lineage choices.
