COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

Wayne F. Leung; Samuel Chorlton; John Tyson; Ghada N. Al-Rawahi; Agatha N. Jassem; Natalie Prystajecky; Shazia Masud; Gregory D. Deans; Michael G. Chapman; Yazdan Mirzanejad; Melanie C.M. Murray; Patrick H.P. Wong

International Journal of Infectious Diseases (Jan 2022)

COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

Wayne F. Leung,
Samuel Chorlton,
John Tyson,
Ghada N. Al-Rawahi,
Agatha N. Jassem,
Natalie Prystajecky,
Shazia Masud,
Gregory D. Deans,
Michael G. Chapman,
Yazdan Mirzanejad,
Melanie C.M. Murray,
Patrick H.P. Wong

Affiliations

Wayne F. Leung: Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Samuel Chorlton: Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
John Tyson: British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada
Ghada N. Al-Rawahi: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Agatha N. Jassem: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada
Natalie Prystajecky: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada
Shazia Masud: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Gregory D. Deans: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Michael G. Chapman: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Yazdan Mirzanejad: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Melanie C.M. Murray: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Patrick H.P. Wong: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Corresponding author. Address: Infectious Diseases Clinic – 1B, Jim Pattison Outpatient Care and Surgery Centre, 9750 140th St, Surrey, British Columbia, V3T 0G9, Canada. Tel.: +1 604 582 4553; fax: +1 604 582 3742. (P.H.P. Wong).

Journal volume & issue: Vol. 114
pp. 178 – 182

Abstract

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ABSTRACT: This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

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Abstract

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