Acta Pharmaceutica Sinica B (May 2017)

Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity

  • Lingjie Meng,
  • Qinglan Guo,
  • Yufeng Liu,
  • Minghua Chen,
  • Yuhuan Li,
  • Jiandong Jiang,
  • Jiangong Shi

DOI
https://doi.org/10.1016/j.apsb.2017.04.003
Journal volume & issue
Vol. 7, no. 3
pp. 334 – 341

Abstract

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Six new indole alkaloid sulfonic acids (1–6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95 (H3N2), respectively.

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