A facile and chemoselectivity in synthesis of 4-chloro-N-(4-((1-hydroxy-2-methylpropan-2-yl)oxy)phenethyl)benzamide, the alcohol derivative of Bezafibrate

Greesha N. Majethia; Wahajul Haq; Ganesaratnam K. Balendiran

Results in Chemistry (Jan 2022)

A facile and chemoselectivity in synthesis of 4-chloro-N-(4-((1-hydroxy-2-methylpropan-2-yl)oxy)phenethyl)benzamide, the alcohol derivative of Bezafibrate

Greesha N. Majethia,
Wahajul Haq,
Ganesaratnam K. Balendiran

Affiliations

Greesha N. Majethia: Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA
Wahajul Haq: Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA
Ganesaratnam K. Balendiran: Corresponding author at: Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA.; Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA

Journal volume & issue: Vol. 4
p. 100417

Abstract

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A facile method for the reduction of carboxylic acid group of Bezafibrate, an approved drug, is described. The selective reduction of carboxylic acid group to corresponding alcohol was carried out by activation of the carboxylic acid moiety via mixed anhydride followed by the addition of stoichiometric amount of NaBH4 and methanol to obtain the first alcohol variant of Bezafibrate. The reaction was completed in 5–10 min in excellent yield and purity. The new alcohol derivative was characterized by spectroscopic methods. This is the first report on this new molecule.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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