Multivariable correlations of estimated glomerular filtration rate in 1020 consecutive PCIs in 16 months from a single center

Abstract

Background: Contrast-induced nephropathy can occur post percutaneous coronary intervention (PCIs). Objectives: To establish the multivariable relationships in all post-PCI patients. Methods: Renal function assessed by calculating estimated glomerular filtration rate using the modification of diet in renal disease formula and then indexed to respective BSA in consecutive 1020 post-PCI patients from June 2021 to September 2022. The complete raw data of various variables were segregated and analyzed in Microsoft Excel under various headings. Then studied for their clinical significance and interrelationships. Statistical significance was studied with number, percentages, maximum, minimum, mean, standard deviation etc., and specific statistics (includes: descriptive statistics provides number, %, interquartile range, etc., correlation statistics-provides Pearson ‘r’ correlation and regression statistics-provides the relationships). Finally, all the results were presented in the form of tables and figures from the data visualization technique. Results: The complete analysis of all 1020 PCI patient’s data suggests that age, left ventricular ejection fraction by two-dimensional echocardiography, body mass index, pre-procedural serum creatinine values and volumes of contrast used, and diastolic blood pressure (BP) has directly related to good cardiorenal outcome. Conclusions: Post-PCI acute kidney injury is a known entity. Renal functions were affected by multiple variables. Prerenal assessment and management, adequate (pre and post-PCI) hydration therapy, avoiding or minimizing nephrotoxic agents, BP control, staged PCI, precision PCI with additional procedures will not only reduce the contrast agent burden on kidney and will have good cardiorenal outcome.

Keywords

• acute kidney injury
• contrast-induced nephropathy
• prerenal failure