Evaluation of hepatokines, proinflammatory cytokines, oxidative stress and energy related metabolism analytes and hematological parameters in dairy cows with placental retention

Abstract

Aim: To investigate the serum levels of angiopoietin-like protein 4 (ANGPTL4), fibroblast growth factor 21 (FGF21), interleukin 1 beta (IL-1Β), IL-6, superoxide dismutase (SOD), malondialdehyde (MDA), and energy-related metabolism analytes and hematological parameters in cows with placental retention (PR). Materials and Methods: In the presented study, blood samples were taken from the coccygeal veins of 10 cows with PR and 10 healthy control cows. All of the samples were analyzed to determine the serum glucose, unesterified fatty acid (NEFA), triglyceride, high-density lipoprotein (HDL), total protein, albumin, aspartate aminotransaminase (AST), SOD, and MDA levels. Blood serum hepatokines, ANGPTL4, FGF21 levels, proinflammatory cytokine response parameters, IL-1 beta, and IL-6 levels were evaluated. Results: As a result, the increase in serum AST (p Conclusion: It was concluded that significant increases in the serum ANGPTL4 and FGF2 levels were associated with energy balance, effective cytokine responses, and oxidative stress in dairy cows with PR.

Keywords

• hepatokines
• oxidative stress
• placental retention
• cytokines
• dairy cows