Diabetes, Metabolic Syndrome and Obesity (May 2023)

Translation Animal Models of Diabetic Kidney Disease: Biochemical and Histological Phenotypes, Advantages and Limitations

  • Luo W,
  • Tang S,
  • Xiao X,
  • Luo S,
  • Yang Z,
  • Huang W,
  • Tang S

Journal volume & issue
Vol. Volume 16
pp. 1297 – 1321

Abstract

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Wenting Luo,1 Shiyun Tang,2 Xiang Xiao,1 Simin Luo,1 Zixuan Yang,1 Wei Huang,3 Songqi Tang1 1School of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan Province, People’s Republic of China; 2Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of China; 3School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of ChinaCorrespondence: Wei Huang, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611137, People’s Republic of China, Email [email protected] Songqi Tang, School of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan Province, 571199, People’s Republic of China, Tel +86 18689713500, Email [email protected]: Animal models play a crucial role in studying the pathogenesis of diseases, developing new drugs, identifying disease risk markers, and improving means of prevention and treatment. However, modeling diabetic kidney disease (DKD) has posed a challenge for scientists. Although numerous models have been successfully developed, none of them can encompass all the key characteristics of human DKD. It is essential to choose the appropriate model according to the research needs, as different models develop different phenotypes and have their limitations. This paper provides a comprehensive overview of biochemical and histological phenotypes, modeling mechanisms, advantages and limitations of DKD animal models, in order to update relevant model information and provide insights and references for generating or selecting the appropriate animal models to fit different experimental needs.Keywords: modeling, advanced diabetic kidney disease, diabetic complications, hypertension, atherosclerosis, non-proteinuric diabetic kidney disease

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