Nature Communications (Jun 2021)
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
- Martin Kosar,
- Michele Giannattasio,
- Daniele Piccini,
- Apolinar Maya-Mendoza,
- Francisco García-Benítez,
- Jirina Bartkova,
- Sonia I. Barroso,
- Hélène Gaillard,
- Emanuele Martini,
- Umberto Restuccia,
- Miguel Angel Ramirez-Otero,
- Massimiliano Garre,
- Eleonora Verga,
- Miguel Andújar-Sánchez,
- Scott Maynard,
- Zdenek Hodny,
- Vincenzo Costanzo,
- Amit Kumar,
- Angela Bachi,
- Andrés Aguilera,
- Jiri Bartek,
- Marco Foiani
Affiliations
- Martin Kosar
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Michele Giannattasio
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Daniele Piccini
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Apolinar Maya-Mendoza
- Danish Cancer Society Research Center
- Francisco García-Benítez
- Centro Andaluz de Biología Molecular y Medicina Regenerativa—CABIMER, Universidad de Sevilla-CSIC
- Jirina Bartkova
- Danish Cancer Society Research Center
- Sonia I. Barroso
- Centro Andaluz de Biología Molecular y Medicina Regenerativa—CABIMER, Universidad de Sevilla-CSIC
- Hélène Gaillard
- Centro Andaluz de Biología Molecular y Medicina Regenerativa—CABIMER, Universidad de Sevilla-CSIC
- Emanuele Martini
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Umberto Restuccia
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Miguel Angel Ramirez-Otero
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Massimiliano Garre
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Eleonora Verga
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Miguel Andújar-Sánchez
- Pathology Department, Complejo Hospitalario Universitario Insular Materno Infantil
- Scott Maynard
- Danish Cancer Society Research Center
- Zdenek Hodny
- Institute of Molecular Genetics of the Czech Academy of Sciences
- Vincenzo Costanzo
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Amit Kumar
- Genome & Cell Integrity Laboratory, CSIR-Indian Institute of Toxicology Research
- Angela Bachi
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- Andrés Aguilera
- Centro Andaluz de Biología Molecular y Medicina Regenerativa—CABIMER, Universidad de Sevilla-CSIC
- Jiri Bartek
- Institute of Molecular Genetics of the Czech Academy of Sciences
- Marco Foiani
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare
- DOI
- https://doi.org/10.1038/s41467-021-24224-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.
