Journal of Otology (Oct 2021)

Peripheral vestibular system: Age-related vestibular loss and associated deficits

  • Jennifer Coto,
  • Carmen L. Alvarez,
  • Ivette Cejas,
  • Brett M. Colbert,
  • Bonnie E. Levin,
  • Joshua Huppert,
  • Tatjana Rundek,
  • Carey Balaban,
  • Susan H. Blanton,
  • David J. Lee,
  • David Loewenstein,
  • Michael Hoffer,
  • Xue Zhong Liu

Journal volume & issue
Vol. 16, no. 4
pp. 258 – 265

Abstract

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Given the interdependence of multiple factors in age-related vestibular loss (e.g., balance, vision, cognition), it is important to examine the individual contributions of these factors with ARVL. While the relationship between the vestibular and visual systems has been well studied (Bronstein et al., 2015), little is known about the association of the peripheral vestibular system with neurodegenerative disorders (Cronin et al., 2017). Further, emerging research developments implicate the vestibular system as an opportunity for examining brain function beyond balance, and into other areas, such as cognition and psychological functioning. Additionally, the bidirectional impact of psychological functioning is understudied in ARVL. Recognition of ARVL as part of a multifaceted aging process will help guide the development of integrated interventions for patients who remain at risk for decline. In this review, we will discuss a wide variety of characteristics of the peripheral vestibular system and ARVL, how it relates to neurodegenerative diseases, and correlations between ARVL and balance, vision, cognitive, and psychological dysfunction. We also discuss clinical implications as well as future directions for research, with an emphasis on improving care for patients with ARVL.

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