Identification of mimicking anti-Ec with literature review: a case report

Abstract

[Objective] To identify a mimicking alloantibody, analyze its serological characteristics and antibody specificity, and explore transfusion strategies for mimicking alloantibody. [Methods] The antibody specificity of patients was identified by direct anti-globulin test, antibody identification, antibody titration test and absorption-elution test. Related literature was retrospectively reviewd. [Results] The anti-Ec was detected in both the diluted serum and elution liquid. The patient's antibody corresponded to antigen negative red blood cells (type O, CCDee) from blood donors who absorb serum and elute anti-Ec. In both serum and elution liquid, the titer detected by E-positive cells was stronger than that by E-negative cells, with a difference of 5-6 tubes in the serum and a difference of 2 tubes in the elution liquid. Thirty articles at home and abroad were reviewed and analyzed, revealing that the distribution of mimicking specificity autoantibodies was mainly in the Rh blood group system, accounting for 86.4%, followed by blood type systems such as Kidd, MNS, Duffy, etc. [Conclusion] The presence of mimicking anti-Ec antibody in the patient's serum was confirmed, with specific and non-specific anti-E antibodies in the mimicking antibody. Reasonable use of antibody titer test, and absorption-elution test can help identify the specificity of anti-E antibodies and provide transfusion strategies for clinical transfusion.

Keywords

• mimicking antibody
• mimicking antibody titer
• cross matching