Nature Communications (Feb 2019)

High-speed mechano-active multielectrode array for investigating rapid stretch effects on cardiac tissue

  • Matthias Imboden,
  • Etienne de Coulon,
  • Alexandre Poulin,
  • Christian Dellenbach,
  • Samuel Rosset,
  • Herbert Shea,
  • Stephan Rohr

DOI
https://doi.org/10.1038/s41467-019-08757-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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While strain is known to affect cardiac electrophysiology, experimental systems to interrogate the effect of rapid strain cycles on cardiac tissue are lacking. Here the authors introduce a multielectrode array that can induce rapid dynamic strain cycles on cardiomyocyte strands and see effects of strain amplitude but not strain rate on impulse conduction.