Nature Communications (Mar 2018)

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

  • In-Gyun Lee,
  • Mara A. Olenick,
  • Malgorzata Boczkowska,
  • Clara Franzini-Armstrong,
  • Erika L. F. Holzbaur,
  • Roberto Dominguez

Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12


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A growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes. Here the authors identify and characterize a conserved mechanism of interaction between dynein and unrelated effector proteins.