Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma

Shunsuke Tanigawa; Etsuko Tanaka; Koichiro Miike; Tomoko Ohmori; Daisuke Inoue; Chen-Leng Cai; Atsuhiro Taguchi; Akio Kobayashi; Ryuichi Nishinakamura

doi:10.1038/s41467-022-28226-7

Nature Communications (Feb 2022)

Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma

Shunsuke Tanigawa,
Etsuko Tanaka,
Koichiro Miike,
Tomoko Ohmori,
Daisuke Inoue,
Chen-Leng Cai,
Atsuhiro Taguchi,
Akio Kobayashi,
Ryuichi Nishinakamura

Affiliations

Shunsuke Tanigawa: Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University
Etsuko Tanaka: Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University
Koichiro Miike: Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University
Tomoko Ohmori: Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University
Daisuke Inoue: Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University
Chen-Leng Cai: Department of Pediatrics, Indiana University School of Medicine
Atsuhiro Taguchi: Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University
Akio Kobayashi: Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University
Ryuichi Nishinakamura: Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University

DOI: https://doi.org/10.1038/s41467-022-28226-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Organs consist of parenchyma and stroma. Nishinakamura and colleagues induce renal stromal progenitors from mouse pluripotent stem cells (PSCs), and generate completely PSC-derived organoids that reproduce complex kidney structure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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