Nature Communications (Jan 2021)

IDH1 mutations induce organelle defects via dysregulated phospholipids

  • Adrian Lita,
  • Artem Pliss,
  • Andrey Kuzmin,
  • Tomohiro Yamasaki,
  • Lumin Zhang,
  • Tyrone Dowdy,
  • Christina Burks,
  • Natalia de Val,
  • Orieta Celiku,
  • Victor Ruiz-Rodado,
  • Elena-Raluca Nicoli,
  • Michael Kruhlak,
  • Thorkell Andresson,
  • Sudipto Das,
  • Chunzhang Yang,
  • Rebecca Schmitt,
  • Christel Herold-Mende,
  • Mark R. Gilbert,
  • Paras N. Prasad,
  • Mioara Larion

DOI
https://doi.org/10.1038/s41467-020-20752-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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The understanding of altered lipid metabolism by isocitrate dehydrogenase 1 (IDH1) mutations in gliomas at a compartment-specific level is limited. Here, the authors use Raman spectroscopy to monitor organelle-specific metabolic changes and report that IDH1 mutations induce phospholipid imbalances which lead to ER and Golgi dilation.