Nature Communications (Jan 2021)
IDH1 mutations induce organelle defects via dysregulated phospholipids
- Adrian Lita,
- Artem Pliss,
- Andrey Kuzmin,
- Tomohiro Yamasaki,
- Lumin Zhang,
- Tyrone Dowdy,
- Christina Burks,
- Natalia de Val,
- Orieta Celiku,
- Victor Ruiz-Rodado,
- Elena-Raluca Nicoli,
- Michael Kruhlak,
- Thorkell Andresson,
- Sudipto Das,
- Chunzhang Yang,
- Rebecca Schmitt,
- Christel Herold-Mende,
- Mark R. Gilbert,
- Paras N. Prasad,
- Mioara Larion
Affiliations
- Adrian Lita
- Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health
- Artem Pliss
- Institute for Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York
- Andrey Kuzmin
- Institute for Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York
- Tomohiro Yamasaki
- Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health
- Lumin Zhang
- Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health
- Tyrone Dowdy
- Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health
- Christina Burks
- Electron Microscopy Laboratory, Frederick National Laboratory for Cancer Research, Center for Cancer Research, National Cancer Institute
- Natalia de Val
- Electron Microscopy Laboratory, Frederick National Laboratory for Cancer Research, Center for Cancer Research, National Cancer Institute
- Orieta Celiku
- Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health
- Victor Ruiz-Rodado
- Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health
- Elena-Raluca Nicoli
- Undiagnosed Diseases Program, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH)
- Michael Kruhlak
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health (NIH)
- Thorkell Andresson
- Protein Characterization Laboratory of the Cancer Research Technology Program (CRTP), National Cancer Institute
- Sudipto Das
- Protein Characterization Laboratory of the Cancer Research Technology Program (CRTP), National Cancer Institute
- Chunzhang Yang
- Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health
- Rebecca Schmitt
- Institute for Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York
- Christel Herold-Mende
- Division of Neurosurgical Research, Department of Neurosurgery, University Hospital Heidelberg
- Mark R. Gilbert
- Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health
- Paras N. Prasad
- Institute for Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York
- Mioara Larion
- Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-020-20752-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
The understanding of altered lipid metabolism by isocitrate dehydrogenase 1 (IDH1) mutations in gliomas at a compartment-specific level is limited. Here, the authors use Raman spectroscopy to monitor organelle-specific metabolic changes and report that IDH1 mutations induce phospholipid imbalances which lead to ER and Golgi dilation.
