Nature Communications (Apr 2018)

Placental miR-340 mediates vulnerability to activity based anorexia in mice

  • Mariana Schroeder,
  • Mira Jakovcevski,
  • Tamar Polacheck,
  • Yonat Drori,
  • Alessia Luoni,
  • Simone Röh,
  • Jonas Zaugg,
  • Shifra Ben-Dor,
  • Christiane Albrecht,
  • Alon Chen

DOI
https://doi.org/10.1038/s41467-018-03836-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Anorexia nervosa is characterised by self-starvation but its etiology is not completely understood. Here the authors describe how prenatal stress can induce activity-based anorexia in the offspring during early adulthood by upregulating miR-340 expression in the placenta that affects expression of nutrient transporters.